Variable domain-linked oligosaccharides of a human monoclonal IgG: structure and influence on antigen binding
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چکیده
منابع مشابه
Variable domain-linked oligosaccharides of a human monoclonal IgG: structure and influence on antigen binding.
The variable-domain-attached oligosaccharide side chains of a human IgG produced by a human-human-mouse heterohybridoma were analysed. In addition to the conserved N-glycosylation site at Asn-297, an N-glycosylation consensus sequence (Asn-Asn-Ser) is located at position 75 in the variable region of its heavy chain. The antibody was cleaved into its antigen-binding (Fab) and crystallizing fragm...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1999
ISSN: 0264-6021
DOI: 10.1042/0264-6021:3380529